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Proteins/UNIPROT:Q9NY64
Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate..
Function from UniProtKB (Q9NY64), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
35 statements
35 statements · 6 reference databases · Subject: SLC2A8 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
beta-D-fructosebeta-D-fructose
Transported by SLC2A9 or SLC2A11 or SLC2A8 or SLC2A5 or SLC2A2 or SLC2A7
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04321CC BY 4.0Reference data
5 names
Resolves to: SLC2A8
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR05029CC BY 4.0Reference data
alpha,alpha-trehalosealpha,alpha-trehalose
Transported by SLC2A8
Reaction pageRight to leftBalanced
Rhea RHEA:17629CC BY 4.0Reference data
Transported by SLC2A2 or SLC2A5 or SLC2A7 or SLC2A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:60372CC BY 4.0Reference data
Transported by SLC2A10 or SLC2A1 or SLC2A2 or SLC2A3 or SLC2A4 or SLC2A7 or SLC2A12 or SLC2A14 or SLC2A11 or SLC2A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:60376CC BY 4.0Reference data
L-dehydroascorbateL-dehydroascorbate
Transported by SLC2A2 or SLC2A14 or SLC2A8
Reaction pageDirection not assertedBalanced
Rhea RHEA:60380CC BY 4.0Reference data