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Proteins/UNIPROT:P07359

GP1BA

Protein·UNIPROT:P07359

Open in the graph

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

Function from UniProtKB (P07359), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

4 rows

autosomal dominant macrothrombocytopenia has a germline basis in GP1BADiseaseGenCC HGNC:4439|MONDO:0015372Inferred only
Bernard-Soulier syndrome has a germline basis in GP1BADiseaseGenCC HGNC:4439|MONDO:0009276Inferred only
Bernard-Soulier syndrome, type A2, autosomal dominant has a germline basis in GP1BADiseaseGenCC HGNC:4439|MONDO:0007930Inferred only
platelet-type von Willebrand disease has a germline basis in GP1BADiseaseGenCC HGNC:4439|MONDO:0008332Inferred only

Statements

35 statements

35 statements · 4 reference databases · Subject: GP1BA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

GP1BA covaries with GLMPProteinHetionet hetionet:covaries:112770-2811Inferred only
SHISA8 covaries with GP1BAProteinHetionet hetionet:covaries:2811-440829Inferred only
DDIT3 interacts with GP1BAProteinHetionet hetionet:interacts:1649-2811Inferred only
F11 interacts with GP1BAProteinHetionet hetionet:interacts:2160-2811Inferred only
F12 interacts with GP1BAProteinHetionet hetionet:interacts:2161-2811Inferred only
FLNB interacts with GP1BAProteinHetionet hetionet:interacts:2317-2811Inferred only
GP1BA interacts with GP5ProteinHetionet hetionet:interacts:2811-2814Inferred only
GP1BA interacts with SELPProteinHetionet hetionet:interacts:2811-6403Inferred only
GP1BA interacts with YWHAZProteinHetionet hetionet:interacts:2811-7534Inferred only
GP1BA participates in 22q11 2 copy number variation syndromePathwayWikiPathways WP4657Inferred only
GP1BA participates in Amplification and propagation of coagulation cascadePathwayReactome R-HSA-9769743Inferred only
GP1BA participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only

Show the remaining 23

GP1BA participates in Defective binding of VWF variant to GPIb:IX:VPathwayReactome R-HSA-9846298Inferred only
GP1BA participates in Defective F9 activationPathwayReactome R-HSA-9673221Inferred only
GP1BA participates in Defective factor IX causes hemophilia BPathwayReactome R-HSA-9668250Inferred only
GP1BA participates in Defects of Coagulation cascadePathwayReactome R-HSA-9769726Inferred only
GP1BA participates in Defects of platelet adhesion to exposed collagenPathwayReactome R-HSA-9823587Inferred only
GP1BA participates in DiseasePathwayReactome R-HSA-1643685Inferred only
GP1BA participates in Diseases of hemostasisPathwayReactome R-HSA-9671793Inferred only
GP1BA participates in Enhanced binding of GP1BA variant to VWF multimer:collagenPathwayReactome R-HSA-9845620Inferred only
GP1BA participates in FXIIa, PKa-dependent activation of coagulation pathwayPathwayReactome R-HSA-9935598Inferred only
GP1BA participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
GP1BA participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
GP1BA participates in GP1b-IX-V activation signallingPathwayReactome R-HSA-430116Inferred only
GP1BA participates in HemostasisPathwayReactome R-HSA-109582Inferred only
GP1BA participates in Network map of SARS CoV 2 signalingPathwayWikiPathways WP5115Inferred only
GP1BA participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
GP1BA participates in Platelet Adhesion to exposed collagenPathwayReactome R-HSA-75892Inferred only
GP1BA participates in Platelet Aggregation (Plug Formation)PathwayReactome R-HSA-76009Inferred only
GP1BA participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
GP1BA participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
GP1BA participates in RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionPathwayReactome R-HSA-8936459Inferred only
GP1BA participates in Transcriptional regulation by RUNX1PathwayReactome R-HSA-8878171Inferred only
GP1BA regulates positive regulation of platelet activationBiological processgene ontology P07359|GO:0010572Inferred only
GP1BA regulates regulation of blood coagulationBiological processgene ontology P07359|GO:0030193Inferred only

Other names

7 names

Resolves to: GP1BA

Also called: [Cleaved into: Glycocalicin]Antigen CD42b-alphaCD antigen CD42bGlycoprotein IbalphaGP-Ib alphaGPIb-alphaGPIbA

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