Loading the page.
Proteins/UNIPROT:O60942
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate..
Function from UniProtKB (O60942), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 3 reference databases · Subject: RNGTT · Sources: Hetionet, Reactome, WikiPathways
4 reactions
MAM01129c+waterphosphate(3-)+MAM02755c
Catalysed by RNGTT
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.33cytosol
Human-GEM MAR09507CC BY 4.0Reference data
MAM00096c+GTPMAM01864c+diphosphate(3-)
Catalysed by RNGTT
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.50cytosol
Human-GEM MAR09508CC BY 4.0Reference data
7 names
Resolves to: RNGTT
a 5'-end triphospho-ribonucleoside in mRNA+watera 5'-end diphospho-ribonucleoside in mRNA+hydrogenphosphate+hydron
Catalysed by RNGTT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67004CC BY 4.0Reference data
a 5'-end diphospho-ribonucleoside in mRNA+GTP+hydrona 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA+diphosphate(3-)
Catalysed by RNGTT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67012CC BY 4.0Reference data