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Proteins/UNIPROT:Q8WWH5
Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation..
Function from UniProtKB (Q8WWH5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
10 statements
10 statements · 2 reference databases · Subject: TRUB1 · Sources: gene ontology, Hetionet
3 reactions
CHEBI:65315CHEBI:65314
Catalysed by TRUB2 or PUS10 or TRUB1
Reaction pageLeft to rightBalanced
Rhea RHEA:42532CC BY 4.0Reference data
a uridine in tRNAa pseudouridine in tRNA
Catalysed by RPUSD2 or TRUB1 or RPUSD4 or PUS7 or RPUSD1 or PUS1
Reaction pageLeft to rightBalance undeterminable
4 names
Resolves to: TRUB1
a uridine in mRNAa pseudouridine in mRNA
Catalysed by TRUB2 or RPUSD3 or RPUSD2 or TRUB1 or RPUSD4 or PUS7 or PUS7L or PUS1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56644CC BY 4.0Reference data