Proteins/UNIPROT:Q96F07

CYFIP2

ProteinUNIPROT:Q96F07

Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)..

Function from UniProtKB (Q96F07), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

complex neurodevelopmental disorder has a germline basis in CYFIP2DiseaseGenCC HGNC:13760|MONDO:0100038Inferred only
developmental and epileptic encephalopathy, 65 has a germline basis in CYFIP2DiseaseGenCC HGNC:13760|MONDO:0033374Inferred only
undetermined early-onset epileptic encephalopathy has a germline basis in CYFIP2DiseaseGenCC HGNC:13760|MONDO:0018614Inferred only

Statements

52 statements

52 statements · 4 reference databases · Subject: CYFIP2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CYFIP2 covaries with ARL4CProteinHetionet hetionet:covaries:10123-26999Inferred only
CYFIP2 covaries with HDLBPProteinHetionet hetionet:covaries:26999-3069Inferred only
CYFIP2 covaries with JOSD2ProteinHetionet hetionet:covaries:126119-26999Inferred only
CYFIP2 covaries with RAB7AProteinHetionet hetionet:covaries:26999-7879Inferred only
CYFIP2 covaries with RPL36ProteinHetionet hetionet:covaries:25873-26999Inferred only
CYFIP2 covaries with RPL8ProteinHetionet hetionet:covaries:26999-6132Inferred only
CYFIP2 covaries with YPEL1ProteinHetionet hetionet:covaries:26999-29799Inferred only
ABI1 interacts with CYFIP2ProteinHetionet hetionet:interacts:10006-26999Inferred only
CYFIP2 interacts with ABI3ProteinHetionet hetionet:interacts:26999-51225Inferred only
BIRC3 interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-330Inferred only
CYFIP2 interacts with BRK1ProteinHetionet hetionet:interacts:26999-55845Inferred only
DNMBP interacts with CYFIP2ProteinHetionet hetionet:interacts:23268-26999Inferred only

Show the remaining 40

FMR1 interacts with CYFIP2ProteinHetionet hetionet:interacts:2332-26999Inferred only
FXR1 interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-8087Inferred only
FXR2 interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-9513Inferred only
NCK1 interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-4690Inferred only
NCKAP1 interacts with CYFIP2ProteinHetionet hetionet:interacts:10787-26999Inferred only
PLG interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-5340Inferred only
SMAD4 interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-4089Inferred only
UBC interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-7316Inferred only
WASF1 interacts with CYFIP2ProteinHetionet hetionet:interacts:26999-8936Inferred only
CYFIP2 interacts with ZC3H12AProteinHetionet hetionet:interacts:26999-80149Inferred only
CYFIP2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CYFIP2 participates in Fcgamma receptor (FCGR) dependent phagocytosisPathwayReactome R-HSA-2029480Inferred only
CYFIP2 participates in FCGR3A-mediated phagocytosisPathwayReactome R-HSA-9664422Inferred only
CYFIP2 participates in Fragile X syndromePathwayWikiPathways WP4549Inferred only
CYFIP2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CYFIP2 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
CYFIP2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CYFIP2 participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
CYFIP2 participates in Leishmania phagocytosisPathwayReactome R-HSA-9664417Inferred only
CYFIP2 participates in Parasite infectionPathwayReactome R-HSA-9664407Inferred only
CYFIP2 participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
CYFIP2 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
CYFIP2 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
CYFIP2 participates in Regulation of actin dynamics for phagocytic cup formationPathwayReactome R-HSA-2029482Inferred only
CYFIP2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
CYFIP2 participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
CYFIP2 participates in RHO GTPases Activate WASPs and WAVEsPathwayReactome R-HSA-5663213Inferred only
CYFIP2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CYFIP2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
CYFIP2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
CYFIP2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
CYFIP2 participates in Signaling by VEGFPathwayReactome R-HSA-194138Inferred only
CYFIP2 participates in VEGFA-VEGFR2 PathwayPathwayReactome R-HSA-4420097Inferred only
CYFIP2 regulates positive regulation of neurotrophin TRK receptor signaling pathwayBiological processgene ontology Q96F07|GO:0051388Inferred only
CYFIP2 regulates positive regulation of proteolysisBiological processgene ontology Q96F07|GO:0045862Inferred only
CYFIP2 regulates regulation of actin filament polymerizationBiological processgene ontology Q96F07|GO:0030833Inferred only
CYFIP2 regulates regulation of postsynapse assemblyBiological processgene ontology Q96F07|GO:0150052Inferred only
PRP4K increases the expression of CYFIP2ProteinHetionet hetionet:regulates:8899-26999Inferred only
PSME1 decreases the expression of CYFIP2ProteinHetionet hetionet:regulates:5720-26999Inferred only
RAB4A increases the expression of CYFIP2ProteinHetionet hetionet:regulates:5867-26999Inferred only

Other names

4 names

Resolves to: CYFIP2

Also called: Cytoplasmic FMR1-interacting protein 2KIAA1168p53-inducible protein 121PIR121

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