Proteins/UNIPROT:Q96DR7

ARHGEF26

ProteinUNIPROT:Q96DR7

Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry..

Function from UniProtKB (Q96DR7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 4 reference databases · Subject: ARHGEF26 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ARHGEF26 covaries with PHLDA3ProteinHetionet hetionet:covaries:23612-26084Inferred only
ARHGEF26 covaries with ZNF444ProteinHetionet hetionet:covaries:26084-55311Inferred only
ARHGEF26 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARHGEF26 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
ARHGEF26 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
ARHGEF26 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
ARHGEF26 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
ARHGEF26 participates in MECP2 and associated Rett syndromePathwayWikiPathways WP3584Inferred only
ARHGEF26 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
ARHGEF26 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
ARHGEF26 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGEF26 participates in RHOG GTPase cyclePathwayReactome R-HSA-9013408Inferred only

Show the remaining 5

ARHGEF26 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGEF26 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
ARHGEF26 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGEF26 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGEF26 regulates regulation of actin cytoskeleton organizationBiological processgene ontology Q96DR7|GO:0032956Inferred only

Other names

3 names

Resolves to: ARHGEF26

Also called: Rho guanine nucleotide exchange factor 26SGEFSH3 domain-containing guanine exchange factor

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