Proteins/UNIPROT:Q96NY8

NECTIN4

ProteinUNIPROT:Q96NY8

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

(Microbial infection) Acts as a receptor for measles virus..

Function from UniProtKB (Q96NY8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

ectodermal dysplasia-syndactyly syndrome has a germline basis in NECTIN4DiseaseGenCC HGNC:19688|MONDO:0013311Inferred only
ectodermal dysplasia-syndactyly syndrome 1 has a germline basis in NECTIN4DiseaseGenCC HGNC:19688|MONDO:0024565Inferred only

Statements

14 statements

14 statements · 4 reference databases · Subject: NECTIN4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

KLHL35 covaries with NECTIN4ProteinHetionet hetionet:covaries:283212-81607Inferred only
SLC17A2 covaries with NECTIN4ProteinHetionet hetionet:covaries:10246-81607Inferred only
TPBGL covaries with NECTIN4ProteinHetionet hetionet:covaries:100507050-81607Inferred only
NECTIN1 interacts with NECTIN4ProteinHetionet hetionet:interacts:5818-81607Inferred only
NECTIN2 interacts with NECTIN4ProteinHetionet hetionet:interacts:5819-81607Inferred only
PICK1 interacts with NECTIN4ProteinHetionet hetionet:interacts:81607-9463Inferred only
NECTIN4 interacts with TIGITProteinHetionet hetionet:interacts:201633-81607Inferred only
NECTIN4 participates in Adherens junctions interactionsPathwayReactome R-HSA-418990Inferred only
NECTIN4 participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
NECTIN4 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
NECTIN4 participates in Cell-cell junction organizationPathwayReactome R-HSA-421270Inferred only
NECTIN4 participates in Measles virus infectionPathwayWikiPathways WP4630Inferred only

Show the remaining 2

NECTIN4 participates in Nectin/Necl trans heterodimerizationPathwayReactome R-HSA-420597Inferred only
NECTIN4 regulates negative regulation of natural killer cell mediated cytotoxicityBiological processgene ontology Q96NY8|GO:0045953Inferred only

Other names

7 names

Resolves to: NECTIN4

Also called: [Cleaved into: Processed poliovirus receptor-related protein 4]Ig superfamily receptor LNIRLNIRNectin cell adhesion molecule 4Poliovirus receptor-related protein 4PRR4PVRL4

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