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Proteins/UNIPROT:Q93015
N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation. In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu. In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp. May act as a tumor suppressor..
Function from UniProtKB (Q93015), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 statements
6 statements · 4 reference databases · Subject: NAA80 · Sources: gene ontology, Hetionet, Human-GEM, WikiPathways
3 reactions
CHEBI:1146900+proton+MAM02538nCHEBI:15351+CHEBI:15650
Catalysed by ZDHHC6 or LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or PORCN or ZDHHC15 or PLA2G15 or ZDHHC2 or NAA60 or PLAAT2 and 21 more alternatives
8 names
Resolves to: NAA80
Human-GEM MAR01091CC BY 4.0Reference data
N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein]+acetyl-CoAN-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein]+coenzyme A(4-)+hydron
Catalysed by NAA80
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:57324CC BY 4.0Reference data
N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein]+acetyl-CoAN-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein]+coenzyme A(4-)+hydron
Catalysed by NAA80
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:57328CC BY 4.0Reference data