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Proteins/UNIPROT:Q3V5L5
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway..
Function from UniProtKB (Q3V5L5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 7 reference databases · Subject: MGAT5B · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
9 names
Resolves to: MGAT5B
Human-GEM MAR00924CC BY 4.0Reference data
N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]+UDP-N-acetyl-alpha-D-glucosamineN(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]+UDP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16921CC BY 4.0Reference data
3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-seryl-[protein]+UDP-N-acetyl-alpha-D-glucosamineO(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-seryl-[protein]+UDP+hydron
Catalysed by MGAT5B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56252CC BY 4.0Reference data
3-O-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl]-L-threonyl-[protein]+UDP-N-acetyl-alpha-D-glucosamineO(3)-{N-acetyl-beta-D-glucosaminyl-(1->2)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-alpha-D-mannosyl}-L-threonyl-[protein]+UDP+hydron
Catalysed by MGAT5B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56256CC BY 4.0Reference data