Proteins/UNIPROT:Q9Y2K1

ZBTB1

ProteinUNIPROT:Q9Y2K1

Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development (By similarity)..

Function from UniProtKB (Q9Y2K1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 2 reference databases · Subject: ZBTB1 · Sources: gene ontology, Hetionet

Order

ZBTB1 covaries with SH2D3AProteinHetionet hetionet:covaries:10045-22890Inferred only
AR interacts with ZBTB1ProteinHetionet hetionet:interacts:22890-367Inferred only
EWSR1 interacts with ZBTB1ProteinHetionet hetionet:interacts:2130-22890Inferred only
LZTR1 interacts with ZBTB1ProteinHetionet hetionet:interacts:22890-8216Inferred only
ZBTB1 interacts with MAML3ProteinHetionet hetionet:interacts:22890-55534Inferred only
SUMO2 interacts with ZBTB1ProteinHetionet hetionet:interacts:22890-6613Inferred only
UBC interacts with ZBTB1ProteinHetionet hetionet:interacts:22890-7316Inferred only
ZBTB25 interacts with ZBTB1ProteinHetionet hetionet:interacts:22890-7597Inferred only
ZBTB1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y2K1|GO:0000122Inferred only
ZBTB1 regulates positive regulation of natural killer cell differentiationBiological processgene ontology Q9Y2K1|GO:0032825Inferred only
ZBTB1 regulates positive regulation of pro-T cell differentiationBiological processgene ontology Q9Y2K1|GO:2000176Inferred only
ZBTB1 regulates positive regulation of T cell differentiationBiological processgene ontology Q9Y2K1|GO:0045582Inferred only

Show the remaining 8

ZBTB1 regulates positive regulation of T cell mediated immunityBiological processgene ontology Q9Y2K1|GO:0002711Inferred only
ZBTB1 regulates regulation of cytokine productionBiological processgene ontology Q9Y2K1|GO:0001817Inferred only
ZBTB1 regulates regulation of immune system processBiological processgene ontology Q9Y2K1|GO:0002682Inferred only
ZBTB1 decreases the expression of BPHLProteinHetionet hetionet:regulates:22890-670Inferred only
CASP3 increases the expression of ZBTB1ProteinHetionet hetionet:regulates:836-22890Inferred only
ZBTB1 increases the expression of CISD1ProteinHetionet hetionet:regulates:22890-55847Inferred only
SMC1A decreases the expression of ZBTB1ProteinHetionet hetionet:regulates:8243-22890Inferred only
XPNPEP1 decreases the expression of ZBTB1ProteinHetionet hetionet:regulates:7511-22890Inferred only

Other names

2 names

Resolves to: ZBTB1

Also called: KIAA0997Zinc finger and BTB domain-containing protein 1

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