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Proteins/UNIPROT:Q9P2N4

ADAMTS9

Protein·UNIPROT:Q9P2N4

Open in the graph

Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). In addition, catalyzes the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation. Is involved in extracellular matrix proteolysis and in ciliary vesicle growth during ciliogenesis in metalloendopeptidase activity dependent manner. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos..

Function from UniProtKB (Q9P2N4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

nephronophthisis has a germline basis in ADAMTS9DiseaseGenCC HGNC:13202|MONDO:0019005Inferred only
nephronophthisis 1 has a germline basis in ADAMTS9DiseaseGenCC HGNC:13202|MONDO:0009728Inferred only

Statements

19 statements

19 statements · 5 reference databases · Subject: ADAMTS9 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

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IGSF1 covaries with ADAMTS9ProteinHetionet hetionet:covaries:3547-56999Inferred only
ADAMTS9 covaries with PRICKLE2ProteinHetionet hetionet:covaries:166336-56999Inferred only
E2F1 interacts with ADAMTS9ProteinHetionet hetionet:interacts:1869-56999Inferred only
LIMS1 interacts with ADAMTS9ProteinHetionet hetionet:interacts:3987-56999Inferred only
ADAMTS9 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
ADAMTS9 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
ADAMTS9 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
ADAMTS9 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
ADAMTS9 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
ADAMTS9 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
ADAMTS9 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ADAMTS9 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only

Show the remaining 7

ADAMTS9 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
ADAMTS9 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
ADAMTS9 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
ADAMTS9 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
ADAMTS9 regulates negative regulation of endothelial cell migrationBiological processgene ontology Q9P2N4|GO:0010596Inferred only
ADAMTS9 regulates negative regulation of sprouting angiogenesisBiological processgene ontology Q9P2N4|GO:1903671Inferred only
ADAMTS9 requires the cofactor Zn(2+)CompoundUniProt Q9P2N4Inferred only

Other names

4 names

Resolves to: ADAMTS9

Also called: ADAM-TS 9ADAM-TS9ADAMTS-9KIAA1312

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