Proteins/UNIPROT:Q9NS73

MBIP

ProteinUNIPROT:Q9NS73

Functions as part of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Together with MOCS2B, inhibits the activity of stress kinase EIF2AK2/PKR; this may lead to effects such as suppression of JNK activation and subsequent stress-responsive transcription, or suppression of eIF2a phosphorylation to favor translation..

Function from UniProtKB (Q9NS73), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

48 statements

48 statements · 3 reference databases · Subject: MBIP · Sources: gene ontology, Hetionet, Reactome

Order

CENPE covaries with MBIPProteinHetionet hetionet:covaries:1062-51562Inferred only
CCDC85B interacts with MBIPProteinHetionet hetionet:interacts:11007-51562Inferred only
MBIP interacts with CEP63ProteinHetionet hetionet:interacts:51562-80254Inferred only
COPS4 interacts with MBIPProteinHetionet hetionet:interacts:51138-51562Inferred only
MBIP interacts with DGCR6LProteinHetionet hetionet:interacts:51562-85359Inferred only
EPB41L3 interacts with MBIPProteinHetionet hetionet:interacts:23136-51562Inferred only
MBIP interacts with EXOC8ProteinHetionet hetionet:interacts:149371-51562Inferred only
FXR2 interacts with MBIPProteinHetionet hetionet:interacts:51562-9513Inferred only
MBIP interacts with KAT14ProteinHetionet hetionet:interacts:51562-57325Inferred only
LIMS1 interacts with MBIPProteinHetionet hetionet:interacts:3987-51562Inferred only
LMNB1 interacts with MBIPProteinHetionet hetionet:interacts:4001-51562Inferred only
MBIP interacts with LMO3ProteinHetionet hetionet:interacts:51562-55885Inferred only

Show the remaining 36

MAP3K12 interacts with MBIPProteinHetionet hetionet:interacts:51562-7786Inferred only
MAPK6 interacts with MBIPProteinHetionet hetionet:interacts:51562-5597Inferred only
MCM7 interacts with MBIPProteinHetionet hetionet:interacts:4176-51562Inferred only
MYD88 interacts with MBIPProteinHetionet hetionet:interacts:4615-51562Inferred only
MBIP interacts with NDEL1ProteinHetionet hetionet:interacts:51562-81565Inferred only
NINL interacts with MBIPProteinHetionet hetionet:interacts:22981-51562Inferred only
PIK3R3 interacts with MBIPProteinHetionet hetionet:interacts:51562-8503Inferred only
MBIP interacts with PLEKHF2ProteinHetionet hetionet:interacts:51562-79666Inferred only
PPFIA1 interacts with MBIPProteinHetionet hetionet:interacts:51562-8500Inferred only
RAP1GDS1 interacts with MBIPProteinHetionet hetionet:interacts:51562-5910Inferred only
RAPGEF1 interacts with MBIPProteinHetionet hetionet:interacts:2889-51562Inferred only
VTA1 interacts with MBIPProteinHetionet hetionet:interacts:51534-51562Inferred only
WDR5 interacts with MBIPProteinHetionet hetionet:interacts:11091-51562Inferred only
MBIP participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
MBIP participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
MBIP participates in Epigenetic regulation by WDR5-containing histone modifying complexesPathwayReactome R-HSA-9917777Inferred only
MBIP participates in Epigenetic regulation of gene expressionPathwayReactome R-HSA-212165Inferred only
MBIP participates in Formation of WDR5-containing histone-modifying complexesPathwayReactome R-HSA-9772755Inferred only
MBIP participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
MBIP participates in HATs acetylate histonesPathwayReactome R-HSA-3214847Inferred only
MBIP regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NS73|GO:0000122Inferred only
MBIP regulates positive regulation of gene expressionBiological processgene ontology Q9NS73|GO:0010628Inferred only
MBIP regulates positive regulation of JNK cascadeBiological processgene ontology Q9NS73|GO:0046330Inferred only
MBIP regulates regulation of cell cycleBiological processgene ontology Q9NS73|GO:0051726Inferred only
MBIP regulates regulation of cell divisionBiological processgene ontology Q9NS73|GO:0051302Inferred only
MBIP regulates regulation of DNA-templated transcriptionBiological processgene ontology Q9NS73|GO:0006355Inferred only
MBIP regulates regulation of embryonic developmentBiological processgene ontology Q9NS73|GO:0045995Inferred only
MBIP regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NS73|GO:0006357Inferred only
MBIP regulates regulation of tubulin deacetylationBiological processgene ontology Q9NS73|GO:0090043Inferred only
ARG1 increases the expression of MBIPProteinHetionet hetionet:regulates:383-51562Inferred only
AXL decreases the expression of MBIPProteinHetionet hetionet:regulates:558-51562Inferred only
EAPP decreases the expression of MBIPProteinHetionet hetionet:regulates:55837-51562Inferred only
PGBD1 increases the expression of MBIPProteinHetionet hetionet:regulates:84547-51562Inferred only
RRP12 decreases the expression of MBIPProteinHetionet hetionet:regulates:23223-51562Inferred only
TWF2 increases the expression of MBIPProteinHetionet hetionet:regulates:11344-51562Inferred only
ZFX decreases the expression of MBIPProteinHetionet hetionet:regulates:7543-51562Inferred only

Other names

2 names

Resolves to: MBIP

Also called: MAPK upstream kinase-binding inhibitory proteinMUK-binding inhibitory protein

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