Compound

phloretin

A natural dihydrochalcone found in apples and many other fruits.

Definition from MeSH (D010693), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:17276ChEBI

Open in the graph

Structure

2D depiction · 3D model shown

Loading the model…

A generated conformer of phloretin — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound
Formula: C15H14O5
Mass: 274.272 g/mol
Charge: 0
InChIKey: VGEREEWJJVICBM-UHFFFAOYSA-N
SMILES: O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

1 entity

1 entities reached.

0 reported hops1 assembled from the scaffold

LCTProteinUNIPROT:P09848substrate ofInferred only8 paths8 endpoints

What the reference databases state

Chemical structure

phlorizin has the functional parent phloretinCompoundChEBI CHEBI:8113Inferred only
trilobatin has the functional parent phloretinCompoundChEBI CHEBI:145829Inferred only

Statements

1 statement

1 statement · 1 reference database · Subject: phloretin · Sources: Rhea

Order

phloretin is a substrate of LCTProteinRhea RHEA:69639Inferred only

Reactions

4 reactions

phloretin+waterCHEBI:16331+CHEBI:16204+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23396CC BY 4.0Reference data
phloretin+UDP-alpha-D-glucosephlorizin+UDP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:51576CC BY 4.0Reference data
phloretin+UDP-alpha-D-glucosetrilobatin+UDP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:65148CC BY 4.0Reference data
phlorizin+waterphloretin+beta-D-glucose
Catalysed by LCT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:69639CC BY 4.0Reference data

Other names

2 names

Resolves to: phloretin

Also called: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
Systematic name: 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one