Proteins/UNIPROT:Q96RE7

NACC1

ProteinUNIPROT:Q96RE7

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines..

Function from UniProtKB (Q96RE7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

NACC1-related neurodevelopmental disorder with epilepsy, cataracts and episodic irritability has a germline basis in NACC1DiseaseGenCC HGNC:20967|MONDO:0800475Inferred only
neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination has a germline basis in NACC1DiseaseGenCC HGNC:20967|MONDO:0044306Inferred only

Statements

17 statements

17 statements · 2 reference databases · Subject: NACC1 · Sources: gene ontology, Hetionet

Order

NACC1 covaries with ATP2C2ProteinHetionet hetionet:covaries:112939-9914Inferred only
BCL6 interacts with NACC1ProteinHetionet hetionet:interacts:112939-604Inferred only
BCOR interacts with NACC1ProteinHetionet hetionet:interacts:112939-54880Inferred only
ENC1 interacts with NACC1ProteinHetionet hetionet:interacts:112939-8507Inferred only
HDAC3 interacts with NACC1ProteinHetionet hetionet:interacts:112939-8841Inferred only
HDAC4 interacts with NACC1ProteinHetionet hetionet:interacts:112939-9759Inferred only
KLHL2 interacts with NACC1ProteinHetionet hetionet:interacts:11275-112939Inferred only
KPNA3 interacts with NACC1ProteinHetionet hetionet:interacts:112939-3839Inferred only
KPNA4 interacts with NACC1ProteinHetionet hetionet:interacts:112939-3840Inferred only
SUMO2 interacts with NACC1ProteinHetionet hetionet:interacts:112939-6613Inferred only
TARDBP interacts with NACC1ProteinHetionet hetionet:interacts:112939-23435Inferred only
UBC interacts with NACC1ProteinHetionet hetionet:interacts:112939-7316Inferred only

Show the remaining 5

ZBTB14 interacts with NACC1ProteinHetionet hetionet:interacts:112939-7541Inferred only
ZBTB6 interacts with NACC1ProteinHetionet hetionet:interacts:10773-112939Inferred only
NACC1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q96RE7|GO:0045892Inferred only
NACC1 regulates positive regulation of cell population proliferationBiological processgene ontology Q96RE7|GO:0008284Inferred only
NACC1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q96RE7|GO:0006357Inferred only

Other names

4 names

Resolves to: NACC1

Also called: BTB/POZ domain-containing protein 14BBTBD14BNAC-1NAC1

← Every protein Find it in the graph →