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Proteins/UNIPROT:Q9BYC5
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Fucosylates the reducing GlcNAc residue in complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs. Fully converts Fc glycoforms containing one or two terminal GlcNAc moieties (G0-GlcNAc and G0)..
Function from UniProtKB (Q9BYC5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
27 statements
27 statements · 4 reference databases · Subject: FUT8 · Sources: Hetionet, Reactome, Rhea, WikiPathways
3 reactions
MAM01950g+MAM02507gMAM01829g+GDP+proton
Catalysed by FUT8
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.68Golgi apparatus
Human-GEM MAR07332CC BY 4.0Reference data
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]+GDP-beta-L-fucosean N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]+GDP
6 names
Resolves to: FUT8
Catalysed by FUT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12985CC BY 4.0Reference data
an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein]+GDP-beta-L-fucosean N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]+GDP+hydron
Catalysed by FUT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:84135CC BY 4.0Reference data