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Proteins/UNIPROT:Q9UI32
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation..
Function from UniProtKB (Q9UI32), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
55 statements
55 statements · 7 reference databases · Subject: GLS2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
L-glutamine+waterL-glutamate(1-)+proton+ammonium
Reaction pageLeft to rightBalancedEC 3.5.1.2, 3.5.1.38cytosol
Human-GEM MAR09802CC BY 4.0Reference data
4 names
Resolves to: GLS2
Reaction pageDirection not assertedBalanced
Rhea RHEA:15889CC BY 4.0Reference data