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Proteins/UNIPROT:P36382

GJA5

Protein·UNIPROT:P36382

Open in the graph

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Function from UniProtKB (P36382), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

atrial fibrillation, familial, 11 has a germline basis in GJA5DiseaseGenCC HGNC:4279|MONDO:0013544Inferred only
familial atrial fibrillation has a germline basis in GJA5DiseaseGenCC HGNC:4279|MONDO:0018054Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: GJA5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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GJA5 covaries with SAMD11ProteinHetionet hetionet:covaries:148398-2702Inferred only
THAP1 covaries with GJA5ProteinHetionet hetionet:covaries:2702-55145Inferred only
GJA5 interacts with AAR2ProteinHetionet hetionet:interacts:25980-2702Inferred only
GJA1 interacts with GJA5ProteinHetionet hetionet:interacts:2697-2702Inferred only
GJA5 interacts with MARK1ProteinHetionet hetionet:interacts:2702-4139Inferred only
GJA5 interacts with PRKACAProteinHetionet hetionet:interacts:2702-5566Inferred only
GJA5 interacts with RIMS3ProteinHetionet hetionet:interacts:2702-9783Inferred only
GJA5 participates in 1q21 1 copy number variation syndromePathwayWikiPathways WP4905Inferred only
GJA5 participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
GJA5 participates in Gap junction assemblyPathwayReactome R-HSA-190861Inferred only
GJA5 participates in Gap junction traffickingPathwayReactome R-HSA-190828Inferred only
GJA5 participates in Gap junction trafficking and regulationPathwayReactome R-HSA-157858Inferred only

Show the remaining 16

GJA5 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
GJA5 participates in NOTCH1 regulation of endothelial cell calcificationPathwayWikiPathways WP3413Inferred only
GJA5 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
GJA5 regulates negative regulation of blood pressureBiological processgene ontology P36382|GO:0045776Inferred only
GJA5 regulates negative regulation of glomerular filtrationBiological processgene ontology P36382|GO:0003105Inferred only
GJA5 regulates positive regulation of cell communication by chemical couplingBiological processgene ontology P36382|GO:0010652Inferred only
GJA5 regulates positive regulation of vasoconstrictionBiological processgene ontology P36382|GO:0045907Inferred only
GJA5 regulates regulation of atrial cardiac muscle cell action potentialBiological processgene ontology P36382|GO:0098910Inferred only
GJA5 regulates regulation of atrial cardiac muscle cell membrane depolarizationBiological processgene ontology P36382|GO:0060371Inferred only
GJA5 regulates regulation of AV node cell action potentialBiological processgene ontology P36382|GO:0098904Inferred only
GJA5 regulates regulation of bundle of His cell action potentialBiological processgene ontology P36382|GO:0098905Inferred only
GJA5 regulates regulation of cardiac muscle contractionBiological processgene ontology P36382|GO:0055117Inferred only
GJA5 regulates regulation of cell communication by electrical couplingBiological processgene ontology P36382|GO:0010649Inferred only
GJA5 regulates regulation of Purkinje myocyte action potentialBiological processgene ontology P36382|GO:0098906Inferred only
GJA5 regulates regulation of ventricular cardiac muscle cell membrane depolarizationBiological processgene ontology P36382|GO:0060373Inferred only
GJA5 regulates regulation of ventricular cardiac muscle cell membrane repolarizationBiological processgene ontology P36382|GO:0060307Inferred only

Other names

2 names

Resolves to: GJA5

Also called: Connexin-40Cx40

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