atrial fibrillation, familial, 11
Findings
No curated finding names atrial fibrillation, familial, 11 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any familial atrial fibrillation in which the cause of the disease is a mutation in the GJA5 gene.
Definition from the Mondo Disease Ontology (MONDO:0013544), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset
HPO, annotations 2026-09-02
Features
4 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Atrial fibrillationHPOHP:0005110
- 21 of 21 reported patients
- Prolonged P waveHPOHP:0034308
- 1 of 1 reported patient
- Prolonged QRS complexHPOHP:0006677
- 1 of 3 reported patients
- Reduced left ventricular ejection fractionHPOHP:0012664
- 0 of 2 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GJA5HGNC:4279
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
- Moderate · Ambry Genetics · Autosomal dominant · 2018
- Moderate · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
3 names
Resolves to: atrial fibrillation, familial, 11
- Also called
- atrial fibrillation, familial, type 11familial atrial fibrillation caused by mutation in GJA5GJA5 familial atrial fibrillation