familial atrial fibrillation
Findings
No curated finding names familial atrial fibrillation yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An autosomal dominant heart condition that causes disruptions in the heart's normal rhythm. This condition is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular.
Definition from the Mondo Disease Ontology (MONDO:0018054), read 2026-09-29. CC BY 4.0.
Features
11 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Atrial fibrillationHPOHP:0005110
- Frequent (30% to 79% of cases)
- Chest painHPOHP:0100749
- Frequent (30% to 79% of cases)
- DyspneaHPOHP:0002094
- Frequent (30% to 79% of cases)
- Exercise intoleranceHPOHP:0003546
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- PalpitationsHPOHP:0001962
- Frequent (30% to 79% of cases)
- SyncopeHPOHP:0001279
- Frequent (30% to 79% of cases)
- VertigoHPOHP:0002321
- Frequent (30% to 79% of cases)
- Myocardial infarctionHPOHP:0001658
- Occasional (5% to 29% of cases)
- Thromboembolic strokeHPOHP:0001727
- Occasional (5% to 29% of cases)
- ThromboembolismHPOHP:0001907
- Occasional (5% to 29% of cases)
Genes
17 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GATA4HGNC:4173
- Supportive · Orphanet · Autosomal dominant · 2021
- GATA5HGNC:15802
- Supportive · Orphanet · Autosomal dominant · 2021
- GATA6HGNC:4174
- Supportive · Orphanet · Autosomal dominant · 2021
- GJA5HGNC:4279
- Supportive · Orphanet · Autosomal dominant · 2021
- KCNA5HGNC:6224
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- Narrower terms (18)
- atrial fibrillation, familial, 1
- atrial fibrillation, familial, 10
- atrial fibrillation, familial, 11
- atrial fibrillation, familial, 12
- atrial fibrillation, familial, 13
- atrial fibrillation, familial, 14
- atrial fibrillation, familial, 15
- atrial fibrillation, familial, 16
- atrial fibrillation, familial, 17
- atrial fibrillation, familial, 18
- atrial fibrillation, familial, 2
- atrial fibrillation, familial, 3
- atrial fibrillation, familial, 4
- atrial fibrillation, familial, 5
- atrial fibrillation, familial, 6
- atrial fibrillation, familial, 7
- atrial fibrillation, familial, 8
- atrial fibrillation, familial, 9
Other names
1 name
Resolves to: familial atrial fibrillation
- Also called
- hereditary atrial fibrillation (disease)