Gap junction trafficking

Gap junctions are intercellular communication channels formed from Cx (connexin) protein subunits (see Segretain and Falk 2004 and Evans et al. 2006 for comprehensive reviews). Connexins are transported to the plasma membrane after oligomerizing into hexameric assemblies called hemichannels (CxHcs) or connexons. Connexons dock head-to-head in the extracellular space with opposing hexameric channels located in the plasma membranes of neighbouring cells. The double membrane channel or gap junction generated directly links the cytoplasms of interacting cells and facilitates the integration and co-ordination of cellular signalling, metabolism, secretion and contraction. In addition to their role in intercellular communication, connexon hemichannels coordinate the release of ATP, glutamate, NAD+ and prostaglandin E2 from the cells. CxHcs open in response to various types of external changes, including mechanical, shear, ionic and ischaemic stress.

Summary from Reactome (R-HSA-190828), read 2026-09-23.