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Proteins/UNIPROT:Q9NVV9
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis..
Function from UniProtKB (Q9NVV9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
31 statements
31 statements · 2 reference databases · Subject: THAP1 · Sources: gene ontology, Hetionet
1 name
Resolves to: THAP1