Pathway
Gap junction assembly
The assembly of gap junctions involves (1) synthesis of connexin polypeptides at endoplasmic reticulum membranes, (2) oligomerization into homomeric- and heteromeric gap junction connexons (hemi-channels), (3) passage through the Golgi stacks, (4) intracellular storage within Trans Golgi membranes, (5) trafficking along microtubules, (6) insertion of connexons into the plasma membrane, (7) lateral diffusion of connexons in the plasma membrane, (8) aggregation of individual gap junction channels into plaques, and (9) stabilization of peripheral microtubule plus-ends by binding to Cx43-based gap junctions (see Segretain and Falk, 2004.)
REACT:R-HSA-190861Reactome
What the reference databases state
Statements
36 statements
36 statements · 1 reference database · Subject: Gap junction assembly · Sources: Reactome
- GJA1 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJA10 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJA3 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJA4 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJA5 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJA8 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJA9 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJB1 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJB2 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJB3 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJB4 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJB5 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
Show the remaining 24
- GJB6 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJB7 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJC1 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJC2 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJD2 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJD3 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- GJD4 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA1A participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA1B participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA1C participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA3C participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA3D participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA3E participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA4A participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBA8 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBAL3 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB1 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB2A participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB2B participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB3 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB4A participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB4B participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB6 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only
- TUBB8 participates in Gap junction assemblyProteinReactome R-HSA-190861Inferred only