Pathway
Signaling by FGFR4
The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. These receptors are key regulators of several developmental processes in which cell fate and differentiation to various tissue lineages are determined. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of cellular responses induced by this large family of growth factors. An alternative, FGF-independent, source of FGFR activation originates from the interaction with cell adhesion molecules, typically in the context of interactions on neural cell membranes and is crucial for neuronal survival and development.
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Upon ligand binding, receptor dimers are formed and their intrinsic tyrosine kinase is activated causing phosphorylation of multiple tyrosine residues on the receptors. These then serve as docking sites for the recruitment of SH2 (src homology-2) or PTB (phosphotyrosine binding) domains of adaptors, docking proteins or signaling enzymes. Signaling complexes are assembled and recruited to the active receptors resulting in a cascade of phosphorylation events.
This leads to stimulation of intracellular signaling pathways that control cell proliferation, cell differentiation, cell migration, cell survival and cell shape, depending on the cell type or stage of maturation.
What the reference databases state
Statements
35 statements
35 statements · 1 reference database · Subject: Signaling by FGFR4 · Sources: Reactome
- BRAF participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- CBL participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF16 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF18 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF19 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF2 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF20 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF23 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF4 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF6 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FGF9 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
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- FGFR4 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FRS2 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- FRS3 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- GAB1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- HRAS participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- KLB participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- MAPK1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- MAPK3 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- MKNK1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- NRAS participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PIK3CA participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PIK3R1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PLCG1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PPP2CA participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PPP2CB participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PPP2R1A participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- PTPN11 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- RPS27A participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- SOS1 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- SPRY2 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- UBA52 participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- UBB participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only
- UBC participates in Signaling by FGFR4ProteinReactome R-HSA-5654743Inferred only