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Proteins/UNIPROT:Q08188
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath..
Function from UniProtKB (Q08188), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
8 statements
8 statements · 2 reference databases · Subject: TGM3 · Sources: Hetionet, UniProt
2 reactions
MAM00201c+MAM01310cMAM00207c+ammonium
Catalysed by TGM1 or TGM5 or F13A1 or TGM3 or F13B or TGM7 or TGM6 or TGM2
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.13cytosol
Human-GEM MAR09496CC BY 4.0Reference data
L-glutaminyl-[protein]+L-lysyl-[protein][protein]-L-lysyl-N(6)-5-L-glutamyl-[protein]
6 names
Resolves to: TGM3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54816CC BY 4.0Reference data