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Proteins/UNIPROT:P01185

AVP

Protein·UNIPROT:P01185

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Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein..

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[Arg-vasopressin]: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2)..

[Neurophysin 2]: Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release..

Function from UniProtKB (P01185), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neurohypophyseal diabetes insipidus has a germline basis in AVPDiseaseGenCC HGNC:894|MONDO:0007450Inferred only

Statements

50 statements

50 statements · 4 reference databases · Subject: AVP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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AVP covaries with CCDC70ProteinHetionet hetionet:covaries:551-83446Inferred only
GNPDA2 covaries with AVPProteinHetionet hetionet:covaries:132789-551Inferred only
PAK2 covaries with AVPProteinHetionet hetionet:covaries:5062-551Inferred only
RALA covaries with AVPProteinHetionet hetionet:covaries:551-5898Inferred only
YWHAZ covaries with AVPProteinHetionet hetionet:covaries:551-7534Inferred only
AVP interacts with AVPR1BProteinHetionet hetionet:interacts:551-553Inferred only
AVP interacts with AVPR2ProteinHetionet hetionet:interacts:551-554Inferred only
AVP interacts with CRYABProteinHetionet hetionet:interacts:1410-551Inferred only
AVP interacts with OXTRProteinHetionet hetionet:interacts:5021-551Inferred only
AVP interacts with TXNDC17ProteinHetionet hetionet:interacts:551-84817Inferred only
AVP participates in Aquaporin-mediated transportPathwayReactome R-HSA-445717Inferred only
AVP participates in BMAL1:CLOCK,NPAS2 activates circadian expressionPathwayReactome R-HSA-1368108Inferred only

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AVP participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
AVP participates in Circadian clockPathwayReactome R-HSA-9909396Inferred only
AVP participates in Circadian rhythm genesPathwayWikiPathways WP3594Inferred only
AVP participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
AVP participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
AVP participates in Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)PathwayReactome R-HSA-5619099Inferred only
AVP participates in Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)PathwayReactome R-HSA-9036092Inferred only
AVP participates in DiseasePathwayReactome R-HSA-1643685Inferred only
AVP participates in Disorders of transmembrane transportersPathwayReactome R-HSA-5619115Inferred only
AVP participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
AVP participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
AVP participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
AVP participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
AVP participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
AVP participates in Organic anion transport by SLCO transportersPathwayReactome R-HSA-879518Inferred only
AVP participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
AVP participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
AVP participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
AVP participates in SLC transporter disordersPathwayReactome R-HSA-5619102Inferred only
AVP participates in SLC-mediated transmembrane transportPathwayReactome R-HSA-425407Inferred only
AVP participates in SLC-mediated transport of organic anionsPathwayReactome R-HSA-9955298Inferred only
AVP participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
AVP participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
AVP participates in Vasopressin regulated water reabsorptionPathwayWikiPathways WP5085Inferred only
AVP participates in Vasopressin regulates renal water homeostasis via AquaporinsPathwayReactome R-HSA-432040Inferred only
AVP participates in Vasopressin-like receptorsPathwayReactome R-HSA-388479Inferred only
AVP participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
AVP regulates negative regulation of apoptotic processBiological processgene ontology P01185|GO:0043066Inferred only
AVP regulates negative regulation of female receptivityBiological processgene ontology P01185|GO:0007621Inferred only
AVP regulates negative regulation of transmission of nerve impulseBiological processgene ontology P01185|GO:0051970Inferred only
AVP regulates positive regulation of cell growthBiological processgene ontology P01185|GO:0030307Inferred only
AVP regulates positive regulation of cell population proliferationBiological processgene ontology P01185|GO:0008284Inferred only
AVP regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P01185|GO:0007204Inferred only
AVP regulates positive regulation of gene expressionBiological processgene ontology P01185|GO:0010628Inferred only
AVP regulates positive regulation of glutamate secretionBiological processgene ontology P01185|GO:0014049Inferred only
AVP regulates positive regulation of prostaglandin biosynthetic processBiological processgene ontology P01185|GO:0031394Inferred only
AVP regulates positive regulation of systemic arterial blood pressureBiological processgene ontology P01185|GO:0003084Inferred only
AVP regulates positive regulation of vasoconstrictionBiological processgene ontology P01185|GO:0045907Inferred only

Other names

6 names

Resolves to: AVP

Also called: ; Neurophysin 2Arginine-vasopressinARVPAVP-NPIINeurophysin-IIVP

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