Pathway

Phase 2 - plateau phase

Phase 2 of the cardiac action potential is the plateau phase which is sustained by a balance of Ca2+ influx through L-type Ca2+ channels (LTCCs) and K+ efflux through the slow delayed rectifier K+ channel 1 (KCNQ1). This phase sustains muscle contraction.

Summary from Reactome (R-HSA-5576893), read 2026-09-23.

REACT:R-HSA-5576893Reactome

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What the reference databases state

Statements

12 statements

12 statements · 1 reference database · Subject: Phase 2 - plateau phase · Sources: Reactome

Order

AKAP9 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
CACNA1C participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
CACNA2D2 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
CACNB1 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
CACNB2 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
CACNG4 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
KCNE1 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
KCNE2 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
KCNE3 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
KCNE4 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
KCNE5 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only
KCNQ1 participates in Phase 2 - plateau phaseProteinReactome R-HSA-5576893Inferred only