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Proteins/UNIPROT:Q9P2W7
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group..
Function from UniProtKB (Q9P2W7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
49 statements
49 statements · 6 reference databases · Subject: B3GAT1 · Sources: Bgee, Hetionet, Human Protein Atlas, Reactome, UniProt, WikiPathways
2 reactions
MAM01906g+UDP-alpha-D-glucuronateMAM00762g+proton+UDP
Catalysed by B3GAT1 or B3GAT2 or B3GAT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.135Golgi apparatus
Human-GEM MAR07205CC BY 4.0Reference data
3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein]+UDP-alpha-D-glucuronate3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP
6 names
Resolves to: B3GAT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24168CC BY 4.0Reference data