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Proteins/UNIPROT:O14983

ATP2A1

Protein·UNIPROT:O149831 compound

Open in the graph

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction..

Function from UniProtKB (O14983), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

Ca(2+)ElementCHEBI:29108Inferred only18 paths9 endpoints

What the reference databases state

GenCC submitters' classifications

1 row

Brody myopathy has a germline basis in ATP2A1DiseaseGenCC HGNC:811|MONDO:0010977Inferred only

Statements

42 statements

42 statements · 7 reference databases · Subject: ATP2A1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Search this listOrder

ATP2A1 covaries with TNNT3ProteinHetionet hetionet:covaries:487-7140Inferred only
ATP2A1 interacts with APPL1ProteinHetionet hetionet:interacts:26060-487Inferred only
ATP2A1 interacts with CFTRProteinHetionet hetionet:interacts:1080-487Inferred only
ATP2A1 interacts with CUL3ProteinHetionet hetionet:interacts:487-8452Inferred only
ATP2A1 interacts with IRS1ProteinHetionet hetionet:interacts:3667-487Inferred only
ATP2A1 interacts with PLNProteinHetionet hetionet:interacts:487-5350Inferred only
ATP2A1 interacts with RNF167ProteinHetionet hetionet:interacts:26001-487Inferred only
ATP2A1 interacts with SLNProteinHetionet hetionet:interacts:487-6588Inferred only
ATP2A1 interacts with TULP3ProteinHetionet hetionet:interacts:487-7289Inferred only
ATP2A1 interacts with UBCProteinHetionet hetionet:interacts:487-7316Inferred only
ATP2A1 participates in 16p11 2 distal deletion syndromePathwayWikiPathways WP4950Inferred only
ATP2A1 participates in Affected pathways in Duchenne muscular dystrophyPathwayWikiPathways WP5356Inferred only

Show the remaining 30

ATP2A1 participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
ATP2A1 participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
ATP2A1 participates in Calcium mediated T cell apoptosis involved in inclusion body myositisPathwayWikiPathways WP5142Inferred only
ATP2A1 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
ATP2A1 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
ATP2A1 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
ATP2A1 participates in Ion homeostasisPathwayReactome R-HSA-5578775Inferred only
ATP2A1 participates in Ion transport by P-type ATPasesPathwayReactome R-HSA-936837Inferred only
ATP2A1 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
ATP2A1 participates in Platelet calcium homeostasisPathwayReactome R-HSA-418360Inferred only
ATP2A1 participates in Platelet homeostasisPathwayReactome R-HSA-418346Inferred only
ATP2A1 participates in Pre-NOTCH Expression and ProcessingPathwayReactome R-HSA-1912422Inferred only
ATP2A1 participates in Pre-NOTCH Processing in GolgiPathwayReactome R-HSA-1912420Inferred only
ATP2A1 participates in Reduction of cytosolic Ca++ levelsPathwayReactome R-HSA-418359Inferred only
ATP2A1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ATP2A1 participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
ATP2A1 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
ATP2A1 regulates negative regulation of endoplasmic reticulum calcium ion concentrationBiological processgene ontology O14983|GO:0032471Inferred only
ATP2A1 regulates negative regulation of striated muscle contractionBiological processgene ontology O14983|GO:0045988Inferred only
ATP2A1 regulates positive regulation of ATPase-coupled calcium transmembrane transporter activityBiological processgene ontology O14983|GO:1901896Inferred only
ATP2A1 regulates positive regulation of calcium ion import into sarcoplasmic reticulumBiological processgene ontology O14983|GO:1902082Inferred only
ATP2A1 regulates positive regulation of cardiac muscle cell contractionBiological processgene ontology O14983|GO:0106134Inferred only
ATP2A1 regulates positive regulation of endoplasmic reticulum calcium ion concentrationBiological processgene ontology O14983|GO:0032470Inferred only
ATP2A1 regulates positive regulation of fast-twitch skeletal muscle fiber contractionBiological processgene ontology O14983|GO:0031448Inferred only
ATP2A1 regulates positive regulation of mitochondrial calcium ion concentrationBiological processgene ontology O14983|GO:0051561Inferred only
ATP2A1 regulates regulation of cardiac conductionBiological processgene ontology O14983|GO:1903779Inferred only
ATP2A1 regulates regulation of striated muscle contractionBiological processgene ontology O14983|GO:0006942Inferred only
ATP2A1 requires the cofactor magnesium(2+)CompoundUniProt O14983Inferred only
Ca(2+) is transported by ATP2A1CompoundRhea RHEA:18105Inferred only
Ca(2+) is transported by ATP2A1CompoundHuman-GEM MAR07629Inferred only

Reactions

2 reactions

ATP+2Ca(2+)+waterADP+2Ca(2+)+proton+phosphate(3-)
Transported by ATP2C1 or ATP2B4 or ATP2C2 or ATP2B3 or ATP2B1 or ATP2A3 or ATP2B2 or ATP2A2 or ATP2A1
Reaction pageLeft to rightBalancedEC 7.2.2.10cytosol, extracellular space

Other names

5 names

Resolves to: ATP2A1

Also called: Calcium pump 1Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoformEndoplasmic reticulum class 1/2 Ca(2+) ATPaseSERCA1SR Ca(2+)-ATPase 1

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Human-GEM MAR07629CC BY 4.0Reference data

Ca(2+)+ATP(4-)+waterCa(2+)+ADP(3-)+hydrogenphosphate+hydron

Transported by ATP2A1 or ATP2C2 or ATP2A2 or ATP2B1 or ATP2B4 or ATP2C1 or ATP2B2 or ATP2B3 or ATP2A3

Reaction pageLeft to rightBalanced

Rhea RHEA:18105CC BY 4.0Reference data