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Proteins/UNIPROT:P20020
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells. May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles..
Function from UniProtKB (P20020), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
46 statements
46 statements · 6 reference databases · Subject: ATP2B1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+Ca(2+)+waterADP+Ca(2+)+proton+phosphate(3-)
Transported by ATP2B4 or ATP2B3 or ATP2B1 or ATP2B2
Reaction pageLeft to rightBalancedEC 7.1.2.1cytosol, extracellular space
Human-GEM MAR00119CC BY 4.0Reference data
3 names
Resolves to: ATP2B1
Transported by ATP2C1 or ATP2B4 or ATP2C2 or ATP2B3 or ATP2B1 or ATP2A3 or ATP2B2 or ATP2A2 or ATP2A1
Reaction pageLeft to rightBalancedEC 7.2.2.10cytosol, extracellular space
Human-GEM MAR07629CC BY 4.0Reference data