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Proteins/UNIPROT:O00631

SLN

Protein·UNIPROT:O00631

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Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity)..

Function from UniProtKB (O00631), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

20 statements

20 statements · 4 reference databases · Subject: SLN · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ATP2A1 interacts with SLNProteinHetionet hetionet:interacts:487-6588Inferred only
EGR1 interacts with SLNProteinHetionet hetionet:interacts:1958-6588Inferred only
PLN interacts with SLNProteinHetionet hetionet:interacts:5350-6588Inferred only
SLN participates in 16p11 2 distal deletion syndromePathwayWikiPathways WP4950Inferred only
SLN participates in Affected pathways in Duchenne muscular dystrophyPathwayWikiPathways WP5356Inferred only
SLN participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
SLN participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
SLN participates in Ion homeostasisPathwayReactome R-HSA-5578775Inferred only
SLN participates in Ion transport by P-type ATPasesPathwayReactome R-HSA-936837Inferred only
SLN participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
SLN participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
SLN regulates negative regulation of ATPase-coupled calcium transmembrane transporter activityBiological processgene ontology O00631|GO:1901895Inferred only

Show the remaining 8

SLN regulates negative regulation of calcium ion importBiological processgene ontology O00631|GO:0090281Inferred only
SLN regulates negative regulation of calcium ion import into sarcoplasmic reticulumBiological processgene ontology O00631|GO:1902081Inferred only
SLN regulates negative regulation of protein-containing complex disassemblyBiological processgene ontology O00631|GO:0043242Inferred only
SLN regulates positive regulation of cold-induced thermogenesisBiological processgene ontology O00631|GO:0120162Inferred only
SLN regulates positive regulation of protein depolymerizationBiological processgene ontology O00631|GO:1901881Inferred only
SLN regulates regulation of ATPase-coupled calcium transmembrane transporter activityBiological processgene ontology O00631|GO:1901894Inferred only
SLN regulates regulation of calcium ion transportBiological processgene ontology O00631|GO:0051924Inferred only
SLN regulates regulation of relaxation of muscleBiological processgene ontology O00631|GO:1901077Inferred only

Other names

1 name

Resolves to: SLN

Also called: Sarcolipin

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