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Papers/PMID:35187746

Sodium benzoate induces neurobehavioral deficits and brain oxido-inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid.

Journal of biochemical and molecular toxicology2022The record

1 finding · 1 compound · 1 endpoint

sodium benzoate

What it reported

How to read these marks

What moved

1 finding

sodium benzoate — activates ACHE
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding
“SB-treated rats showed a decrease in antioxidant enzyme activities, increase malondialdehyde (MDA), nitrite, tumor necrosis factor-alpha, caspase-3, and acetylcholinesterase activity in the striatum, hippocampus, frontal cortex, and cerebellum.”
Quoted verbatim from Sodium benzoate induces neurobehavioral deficits and brain oxido-inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid..
Study

animal · not in humans
Duration

4 weeks
Population

male Wistar rats, brain tissue (striatum, hippocampus, frontal cortex, cerebellum)
Sodium benzoate induces neurobehavioral deficits and brain oxido-inflammatory stress in male Wistar rats: Ameliorative role of ascorbic acid.2022PMID:35187746Permalink