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Proteins/UNIPROT:Q9Y4Z2

NEUROG3

Protein·UNIPROT:Q9Y4Z2

Open in the graph

Is a transcriptional regulator involved in the control of enteroendocrine cell differentiation. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity)..

Function from UniProtKB (Q9Y4Z2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

congenital malabsorptive diarrhea 4 has a germline basis in NEUROG3DiseaseGenCC HGNC:13806|MONDO:0012479Inferred only
permanent neonatal diabetes mellitus has a germline basis in NEUROG3DiseaseGenCC HGNC:13806|MONDO:0100164Inferred only

Statements

10 statements

10 statements · 2 reference databases · Subject: NEUROG3 · Sources: gene ontology, Reactome

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NEUROG3 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
NEUROG3 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
NEUROG3 participates in Developmental Lineage of Pancreatic Endocrine Mid Progenitor CellsPathwayReactome R-HSA-9981148Inferred only
NEUROG3 participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
NEUROG3 participates in Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cellsPathwayReactome R-HSA-210746Inferred only
NEUROG3 participates in Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cellsPathwayReactome R-HSA-210744Inferred only
NEUROG3 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y4Z2|GO:0000122Inferred only
NEUROG3 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q9Y4Z2|GO:0045893Inferred only
NEUROG3 regulates positive regulation of neuron differentiationBiological processgene ontology Q9Y4Z2|GO:0045666Inferred only
NEUROG3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y4Z2|GO:0045944Inferred only

Other names

7 names

Resolves to: NEUROG3

Also called: ATOH5atonal homolog 5BHLHA7Class A basic helix-loop-helix protein 7NGN-3NGN3Protein atonal homolog 5

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