Proteins/UNIPROT:Q8N9I0

SYT2

ProteinUNIPROT:Q8N9I0

Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes..

Function from UniProtKB (Q8N9I0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

congenital myasthenic syndrome 7 has a germline basis in SYT2DiseaseGenCC HGNC:11510|MONDO:0014468Inferred only
myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive has a germline basis in SYT2DiseaseGenCC HGNC:11510|MONDO:0030341Inferred only

Statements

26 statements

26 statements · 5 reference databases · Subject: SYT2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Order

SYT2 covaries with ARL8AProteinHetionet hetionet:covaries:127829-127833Inferred only
LMOD1 covaries with SYT2ProteinHetionet hetionet:covaries:127833-25802Inferred only
OR2A14 covaries with SYT2ProteinHetionet hetionet:covaries:127833-135941Inferred only
KLHL3 interacts with SYT2ProteinHetionet hetionet:interacts:127833-26249Inferred only
STON2 interacts with SYT2ProteinHetionet hetionet:interacts:127833-85439Inferred only
SYNCRIP interacts with SYT2ProteinHetionet hetionet:interacts:10492-127833Inferred only
UBC interacts with SYT2ProteinHetionet hetionet:interacts:127833-7316Inferred only
WNK1 interacts with SYT2ProteinHetionet hetionet:interacts:127833-65125Inferred only
SYT2 participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only
SYT2 participates in Cargo recognition for clathrin-mediated endocytosisPathwayReactome R-HSA-8856825Inferred only
SYT2 participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
SYT2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 14

SYT2 participates in Hippocampal synaptogenesis and neurogenesisPathwayWikiPathways WP5231Inferred only
SYT2 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
SYT2 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
SYT2 participates in Neurexins and neuroliginsPathwayReactome R-HSA-6794361Inferred only
SYT2 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
SYT2 participates in Neurotoxicity of clostridium toxinsPathwayReactome R-HSA-168799Inferred only
SYT2 participates in Protein-protein interactions at synapsesPathwayReactome R-HSA-6794362Inferred only
SYT2 participates in Toxicity of botulinum toxin type B (botB)PathwayReactome R-HSA-5250958Inferred only
SYT2 participates in Uptake and actions of bacterial toxinsPathwayReactome R-HSA-5339562Inferred only
SYT2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
SYT2 regulates positive regulation of dendrite extensionBiological processgene ontology Q8N9I0|GO:1903861Inferred only
SYT2 regulates regulation of calcium ion-dependent exocytosisBiological processgene ontology Q8N9I0|GO:0017158Inferred only
SYT2 regulates regulation of synaptic vesicle exocytosisBiological processgene ontology Q8N9I0|GO:2000300Inferred only
SYT2 requires the cofactor Ca(2+)CompoundUniProt Q8N9I0Inferred only

Other names

2 names

Resolves to: SYT2

Also called: Synaptotagmin IISytII

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