Loading the page.
Proteins/UNIPROT:O95197
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition..
(Microbial infection) Plays a positive role in viral replication and pathogenesis of enteroviruses..
Function from UniProtKB (O95197), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
33 statements
33 statements · 4 reference databases · Subject: RTN3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
9 names
Resolves to: RTN3