Proteins/UNIPROT:O75334

PPFIA2

ProteinUNIPROT:O75334

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines..

Function from UniProtKB (O75334), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 3 reference databases · Subject: PPFIA2 · Sources: gene ontology, Hetionet, Reactome

Order

FOXL2 covaries with PPFIA2ProteinHetionet hetionet:covaries:668-8499Inferred only
HOXC12 covaries with PPFIA2ProteinHetionet hetionet:covaries:3228-8499Inferred only
RPL13 covaries with PPFIA2ProteinHetionet hetionet:covaries:6137-8499Inferred only
TMEM238 covaries with PPFIA2ProteinHetionet hetionet:covaries:388564-8499Inferred only
CAST interacts with PPFIA2ProteinHetionet hetionet:interacts:831-8499Inferred only
CDC5L interacts with PPFIA2ProteinHetionet hetionet:interacts:8499-988Inferred only
PPFIA2 interacts with ERC2ProteinHetionet hetionet:interacts:26059-8499Inferred only
PPFIA2 interacts with GIT1ProteinHetionet hetionet:interacts:28964-8499Inferred only
PPFIA2 interacts with PPFIA1ProteinHetionet hetionet:interacts:8499-8500Inferred only
PPFIA2 interacts with PPFIA3ProteinHetionet hetionet:interacts:8499-8541Inferred only
PPFIBP1 interacts with PPFIA2ProteinHetionet hetionet:interacts:8496-8499Inferred only
PPFIBP2 interacts with PPFIA2ProteinHetionet hetionet:interacts:8495-8499Inferred only

Show the remaining 17

PTPRF interacts with PPFIA2ProteinHetionet hetionet:interacts:5792-8499Inferred only
PTPRG interacts with PPFIA2ProteinHetionet hetionet:interacts:5793-8499Inferred only
PTPRS interacts with PPFIA2ProteinHetionet hetionet:interacts:5802-8499Inferred only
UBC interacts with PPFIA2ProteinHetionet hetionet:interacts:7316-8499Inferred only
PPFIA2 participates in Acetylcholine Neurotransmitter Release CyclePathwayReactome R-HSA-264642Inferred only
PPFIA2 participates in Dopamine Neurotransmitter Release CyclePathwayReactome R-HSA-212676Inferred only
PPFIA2 participates in Glutamate Neurotransmitter Release CyclePathwayReactome R-HSA-210500Inferred only
PPFIA2 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
PPFIA2 participates in Neurotransmitter release cyclePathwayReactome R-HSA-112310Inferred only
PPFIA2 participates in Norepinephrine Neurotransmitter Release CyclePathwayReactome R-HSA-181430Inferred only
PPFIA2 participates in Protein-protein interactions at synapsesPathwayReactome R-HSA-6794362Inferred only
PPFIA2 participates in Receptor-type tyrosine-protein phosphatasesPathwayReactome R-HSA-388844Inferred only
PPFIA2 participates in Serotonin Neurotransmitter Release CyclePathwayReactome R-HSA-181429Inferred only
PPFIA2 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
PPFIA2 regulates regulation of dendritic spine developmentBiological processgene ontology O75334|GO:0060998Inferred only
PPFIA2 regulates regulation of dendritic spine morphogenesisBiological processgene ontology O75334|GO:0061001Inferred only
PPFIA2 regulates regulation of synaptic vesicle exocytosisBiological processgene ontology O75334|GO:2000300Inferred only

Other names

3 names

Resolves to: PPFIA2

Also called: Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2PTPRF-interacting protein alpha-2tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2

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