N-(9Z-octadecenoyl)-sphinganine

Three steps

• an N(2)-acyl-L-glutamineReach from here →
  1. H2O[g] + N-(9Z-octadecenoyl)-sphinganine[g] = elaidate[g] + sphinganine[g]
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACER3, GLYATL1B, GLYATL1Golgi apparatus, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. H2O[r] + N-(9Z-octadecenoyl)-sphinganine[r] = oleate[r] + sphinganine[r]
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACER3, CERS1, CERS6, CERS3 and 11 moreendoplasmic reticulum, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. H2O[r] + N-(9Z-octadecenoyl)-sphinganine[r] = oleate[r] + sphinganine[r]
  2. sphingosine N-acyltransferase (sphinganine)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACER3, CERS1, CERS6, CERS3 and 11 moreendoplasmic reticulum, cytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. H2O[g] + N-(9Z-octadecenoyl)-sphinganine[g] = elaidate[g] + sphinganine[g]
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACER3, ACAA1, SCP2, ACAA2 and 1 moreGolgi apparatus, cytosol