3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA

Three steps

• (3E)-decenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CoA = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + acetyl-CoA
  2. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 5 morecytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CoA = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + acetyl-CoA
  2. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 4 morecytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CoA = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACAA1, GLYATL1B, GLYATL1cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CoA = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + acetyl-CoA
  2. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 9 morecytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CoA = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + acetyl-CoA
  2. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACAA1, ACOT7, BAAT, THEM4 and 9 morecytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CoA = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + acetyl-CoA
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol