D-glyceraldehyde 3-phosphate

Three steps

• alpha-D-glucose 1-phosphateReach from here →
  1. D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)
  2. 3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase
  3. O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]

  Catalysed by GAPDHS, GAPDH, PGM2L1, PGM1 and 1 morecytosolOne of 2 routes

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
  3. a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)

  Catalysed by TPI1, GNPAT, AGPS

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by TKFC, AKR1A1, AKR1B1, PLA2G4AOne of 2 routes

• 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerolReach from here →
  1. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by TKFC, AKR1A1, AKR1B1, PLA2G4A

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by TKFC, AKR1A1, AKR1B1, PLA2G4A

• 1-O-hexadecylglycerone 3-phosphateReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by TPI1, GNPAT, AGPS

• hexadecanoateReach from here →
  1. D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
  2. dihydroxyacetone phosphate + hexadecanoyl-CoA = 1-hexadecanoylglycerone 3-phosphate + CoA
  3. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)

  Catalysed by TPI1, GNPAT, AGPSOne of 2 routes