dodecanoyl-CoA

Three steps

• O-hexanoyl-(R)-carnitineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  3. hexanoyl-CoA + (R)-carnitine = O-hexanoyl-(R)-carnitine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2 and 1 morecytosol

• O-3-oxobutanoyl-(R)-carnitineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  3. acetoacetyl-CoA + (R)-carnitine = O-3-oxobutanoyl-(R)-carnitine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, CPT2 and 1 morecytosol

• (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 10 morecytosol, endoplasmic reticulumOne of 6 routes

• N-eicosanoylglycinateReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 8 morecytosolOne of 2 routes

• N-docosanoylglycineReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 8 morecytosolOne of 2 routes

• N-hexacosanoylglycineReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 8 morecytosolOne of 2 routes

• (2E,5Z)-tetradecadienoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (physeteric acid)
  3. medium-chain acyl-CoA dehydrogenase (5-tetradecenoyl-CoA)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 12 morecytosol, mitochondrial matrixOne of 4 routes

• (2E,7Z)-hexadecadienoyl-CoAReach from here →
  1. Lauroyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
  3. medium-chain acyl-CoA dehydrogenase (7-hexadecenoyl-CoA)

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 12 morecytosol, mitochondrial matrixOne of 4 routes

• cholesteryl (11Z)-octadecenoateReach from here →
  1. Lauroyl-CoA hydrolase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
  3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 4 morecytosol

• taurochenodeoxycholateReach from here →
  1. Lauroyl-CoA hydrolase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by ACOT7, BAAT, ACOT1, ACOT13 and 3 morecytosol, peroxisomeOne of 5 routes