acetate

Three steps

• O-3-oxobutanoyl-(R)-carnitineReach from here →
  1. transport of acetate and acetoacetate (cytosol to extracellular)
  2. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate
  3. acetoacetyl-CoA + (R)-carnitine = O-3-oxobutanoyl-(R)-carnitine + CoA

  Catalysed by SLC16A4, SLC16A5, SLC16A6, SLC16A7 and 3 moreextracellular space, cytosol

• 6beta-hydroxyandrost-4-ene-3,17-dioneReach from here →
  1. cytochrome P450 (17alpha-hydroxyprogesterone)
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxyandrost-4-ene-3,17-dione + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CYP17A1, CYP3A4, CYP3A5endoplasmic reticulum, cytosol

• thromboxane B2Reach from here →
  1. transport of acetate and pyruvate (cytosol to extracellular)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 7 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• thiamine(1+) diphosphateReach from here →
  1. transport of acetate and pyruvate (cytosol to extracellular)
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 5 moreextracellular space, cytosol, mitochondrial matrix