D-aspartate

Three steps

• tricosanoyl-CoAReach from here →
  1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 4 routes

• 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphateReach from here →
  1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
  2. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
  3. aldehydo-D-mannose 6-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate + phosphate

  Catalysed by DDO, PCK1, PCK2, NANS

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. D-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)
  2. Oxaloacetate Decarboxylase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by DDO, FAHD1, PDHA1, PDHB and 1 morecytosol, mitochondrial matrix