K(+)

Three steps

• N-docosanoylglycineReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC1A1, SLC3A2, SLC7A5, SLC7A8 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreinner side of the membrane, outer side of the membrane

• (7Z)-hexadecenoyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 10 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• thromboxane B2Reach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. transport of serotonin (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC6A4, SLCO1A2, SLCO1B3, SLC7A9inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by SLC1A1, CTH, PDHA1, PDHB and 1 moreinner side of the membrane, outer side of the membrane, cytosol, mitochondrial matrix