a dicarboxylate

Three steps

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

  Catalysed by SLC22A6, TBXAS1, CYP2S1, PTGES2inner side of the membrane, outer side of the membrane, cytosol

• thromboxane B2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLC22A6, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• an S-substituted glutathioneReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC22A6, SLC22A13, GSTT4, GSTA4 and 21 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• 19-hydroxyprostaglandin H2Reach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. prostaglandin-F synthase (prostaglandin F2alpha)
  3. prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLC22A6, CYP4F8inner side of the membrane, outer side of the membrane, cytosol

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC22A6, SLC22A13, GPX1, GSTA1 and 2 moreinner side of the membrane, outer side of the membrane

• taurochenodeoxycholateReach from here →
  1. prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLC22A6, SLCO1B1, SLCO1A2, SLC7A9 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 5 routes