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Reach

dodecanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

400 compounds within 3 steps: 12 in 1, 49 in 2, 339 in 3

Does it reach a compound?

Two steps

1-dodecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. long-chain-fatty-acid-CoA ligase (lauric acid)
2. 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol
beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
1. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
2. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 1 more
1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. long-chain-fatty-acid-CoA ligase (lauric acid)
2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. long-chain-fatty-acid-CoA ligase (lauric acid)
2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol
O-dodecanoyl-R-carnitineReach from here →
1. long-chain-fatty-acid-CoA ligase (lauric acid)
2. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 4 routes
(11Z,14Z)-eicosadienoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
No catalyst recordedcytosol, extracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
No catalyst recordedcytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
No catalyst recordedcytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
No catalyst recordedcytosol, extracellular spaceOne of 12 routes
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
No catalyst recordedcytosol, extracellular spaceOne of 12 routes
tricosanoateReach from here →
1. (10Z)-heptadecenoic acid formation
2. (10Z)-heptadecenoic acid formation
No catalyst recordedcytosol, extracellular spaceOne of 12 routes

Three steps

(S)-carnitineReach from here →
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 11 morecytosolOne of 267 routes
AReach from here →
Catalysed by

Page 2 of 8

PTGS1

, PTGS2

cytosol, extracellular space

One of 12 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP1A2, CYP3A4, CYP2C8 and 4 morecytosol, extracellular space

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP1A2, CYP3A4, CYP2C8 and 4 morecytosol, extracellular space

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C8, CYP2C9, CYP2C19, CYP2J2 and 1 morecytosol, extracellular space

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP2C8, CYP2D6, CYP2C9 and 3 morecytosol, extracellular space

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP2C9, CYP2J2cytosol, extracellular space

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1, CYP2D6, CYP2C9, CYP2C19 and 2 morecytosol, extracellular space

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 morecytosol, extracellular spaceOne of 4 routes

decanoyl-4'-phosphopantetheineReach from here →

long-chain-fatty-acid-CoA ligase (lauric acid)
Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 9 morecytosol, mitochondrial matrix

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
unspecific monooxygenase (arachidonate)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 22 morecytosol, extracellular spaceOne of 2 routes

tetradecanoyl-4'-phosphopantetheineReach from here →

long-chain-fatty-acid-CoA ligase (lauric acid)
fatty-acyl-CoA synthase (N-C14:0CoA)
tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP1A1cytosol, extracellular space

an acyl-4'-phosphopantetheineReach from here →

long-chain-fatty-acid-CoA ligase (lauric acid)
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosol

21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
DHA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 21-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate[r]

Catalysed by CYP2E1cytosol, extracellular space, endoplasmic reticulumOne of 3 routes

13-hydroxytetradecanoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
myristic acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 13-hydroxytetradecanoate[r]

Catalysed by CYP2E1cytosol, extracellular space, endoplasmic reticulumOne of 3 routes

(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Catalysed by PTGS2cytosol, extracellular space

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by PTGS2cytosol, extracellular space

prostaglandin G1Reach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

Catalysed by PTGS2cytosol, extracellular space

prostaglandin G3Reach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3

Catalysed by PTGS2cytosol, extracellular space

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP3A4, CYP2C9cytosol, extracellular space

(17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

Catalysed by ALOX5, ALOX15cytosol, extracellular space

14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate

Catalysed by ALOX15cytosol, extracellular space

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by ALOX15cytosol, extracellular space

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by ALOX15cytosol, extracellular space

19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoateReach from here →

(10Z)-heptadecenoic acid formation
(10Z)-heptadecenoic acid formation
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)