5(S)-HPETE

Three steps

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• ursodeoxycholateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

• prostaglandin G2Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• glycodeoxycholateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

• thromboxane B2Reach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

• an S-substituted glutathioneReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 29 morecytosolOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. Glutathione: 5-HPETE oxidoreductase
  2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

• taurochenodeoxycholateReach from here →
  1. arachidonate:oxygen 5-oxidoreductase
  2. transport of leukotriene A4 (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLC7A9 and 1 morecytosol, extracellular spaceOne of 5 routes