CHEBI:12947

Three steps

• cholesteryl (5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. galactosylceramidase (D-galactosyl-N-acylsphingosine)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z)-eicosatrienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GALC, GBA1, GBA2, LCATlysosome

• (6Z,9Z,12Z-octadecatrienoyl)-cholesterolReach from here →
  1. galactosylceramidase (D-galactosyl-N-acylsphingosine)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by GALC, GBA1, GBA2, LCATlysosome

• cholesteryl (11Z)-octadecenoateReach from here →
  1. galactosylceramidase (D-galactosyl-N-acylsphingosine)
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA

  Catalysed by GALC, GBA1, GBA2, SOAT1lysosome

• beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucoseReach from here →
  1. galactosylceramidase (D-galactosyl-N-acylsphingosine)
  2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
  3. lactose + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)

  Catalysed by GALC, B4GALT2, B4GALT1, FUT3 and 1 morelysosome

• tricosanoyl-CoAReach from here →
  1. galactosylceramidase (D-galactosyl-N-acylsphingosine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. acyl-CoA pool formation and breakdown

  Catalysed by GALC, ASAH1, ACER2, ACER1 and 1 morelysosome, Golgi apparatus, cytosol

• a 3-oxoacyl-CoAReach from here →
  1. galactosylceramidase (D-galactosyl-N-acylsphingosine)
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by GALC, ASAH1, ACER2, ACER1 and 5 morelysosome, Golgi apparatus