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Proteins/UNIPROT:Q92838

EDA

Protein·UNIPROT:Q92838

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Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion (By similarity)..

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[Isoform 1]: Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R..

[Isoform 3]: Binds only to the receptor EDA2R..

Function from UniProtKB (Q92838), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

tooth agenesis has a germline basis in EDADiseaseGenCC HGNC:3157|MONDO:0005486Inferred only
tooth agenesis, selective, X-linked, 1 has a germline basis in EDADiseaseGenCC HGNC:3157|MONDO:0010741Inferred only
X-linked hypohidrotic ectodermal dysplasia has a germline basis in EDADiseaseGenCC HGNC:3157|MONDO:0010585Inferred only

Statements

14 statements

14 statements · 4 reference databases · Subject: EDA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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EDA covaries with NAGKProteinHetionet hetionet:covaries:1896-55577Inferred only
EDA interacts with EDA2RProteinHetionet hetionet:interacts:1896-60401Inferred only
EDA interacts with EDARProteinHetionet hetionet:interacts:10913-1896Inferred only
EDA interacts with FURINProteinHetionet hetionet:interacts:1896-5045Inferred only
EDA participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
EDA participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
EDA participates in Ectoderm differentiationPathwayWikiPathways WP2858Inferred only
EDA participates in EDA signaling in hair follicle developmentPathwayWikiPathways WP3930Inferred only
EDA participates in Hair follicle development organogenesis stage 2 of 3PathwayWikiPathways WP2839Inferred only
EDA participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
EDA participates in TNFR2 non-canonical NF-kB pathwayPathwayReactome R-HSA-5668541Inferred only
EDA participates in TNFs bind their physiological receptorsPathwayReactome R-HSA-5669034Inferred only

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EDA regulates positive regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q92838|GO:0043123Inferred only
EDA regulates regulation of non-canonical NF-kappaB signal transductionBiological processgene ontology Q92838|GO:1901222Inferred only

Other names

5 names

Resolves to: EDA

Also called: [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]Ectodermal dysplasia proteinED1EDA proteinEDA2

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