tooth agenesis, selective, 1
Findings
No curated finding names tooth agenesis, selective, 1 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any tooth agenesis in which the cause of the disease is a mutation in the MSX1 gene characterized by varying severity of tooth agenesis that may be seen in combination with orofacial clefting in some individuals.
Definition from the Mondo Disease Ontology (MONDO:0007129), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
1 feature
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HypodontiaHPOHP:0000668
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- MSX1HGNC:7391
- Definitive · ClinGen · Autosomal dominant · 2024
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2021
- Strong · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
5 names
Resolves to: tooth agenesis, selective, 1
- Also called
- MSX1 tooth agenesisMSX1-related tooth agenesis with or without orofacial clefttooth agenesis caused by mutation in MSX1tooth agenesis, selective, 1, with or without orofacial clefttooth agenesis, selective, type 1