Proteins/UNIPROT:P60323

NANOS3

ProteinUNIPROT:P60323

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis..

Function from UniProtKB (P60323), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

primary ovarian failure has a germline basis in NANOS3DiseaseGenCC HGNC:22048|MONDO:0005387Inferred only

Statements

11 statements

11 statements · 4 reference databases · Subject: NANOS3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

NANOS3 covaries with DDX24ProteinHetionet hetionet:covaries:342977-57062Inferred only
NANOS3 covaries with GNAI3ProteinHetionet hetionet:covaries:2773-342977Inferred only
KLLN covaries with NANOS3ProteinHetionet hetionet:covaries:100144748-342977Inferred only
PCDHB15 covaries with NANOS3ProteinHetionet hetionet:covaries:342977-56121Inferred only
UFSP1 covaries with NANOS3ProteinHetionet hetionet:covaries:342977-402682Inferred only
NANOS3 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
NANOS3 participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
NANOS3 participates in Specification of primordial germ cellsPathwayReactome R-HSA-9827857Inferred only
NANOS3 regulates negative regulation of translationBiological processgene ontology P60323|GO:0017148Inferred only
NANOS3 regulates regulation of cell cycleBiological processgene ontology P60323|GO:0051726Inferred only
NANOS3 regulates regulation of translationBiological processgene ontology P60323|GO:0006417Inferred only

Other names

3 names

Resolves to: NANOS3

Also called: Nanos homolog 3NOS-3NOS3

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