atrial fibrillation, familial, 6
Findings
No curated finding names atrial fibrillation, familial, 6 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any familial atrial fibrillation in which the cause of the disease is a mutation in the NPPA gene.
Definition from the Mondo Disease Ontology (MONDO:0012816), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Young adult onset
HPO, annotations 2026-09-02
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Atrial fibrillationHPOHP:0005110
- 11 of 11 reported patients
- Left atrial enlargementHPOHP:0031295
- 7 of 11 reported patients
- Elevated left ventricular end-diastolic diameterHPOHP:0034307
- 5 of 11 reported patients
- Left ventricular hypertrophyHPOHP:0001712
- 0 of 11 reported patients
- Reduced left ventricular ejection fractionHPOHP:0012664
- 0 of 11 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- NPPAHGNC:7939
- Moderate · Ambry Genetics · Autosomal dominant · 2018
- Moderate · PanelApp Australia · Autosomal dominant · 2025
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2017
Where it sits
- A kind of
Other names
3 names
Resolves to: atrial fibrillation, familial, 6
- Also called
- atrial fibrillation, familial, type 6familial atrial fibrillation caused by mutation in NPPANPPA familial atrial fibrillation